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Relationship of leptin hormone with body mass index and waist circumference in type 2 diabetes and non-diabetes in Sudanese

Journal of Diabetes, Metabolic Disorders & Control
Nahla Ahmed Mohamed,1 Badr Eldeen Elsooni Abdelllah,2 Abderahman Ahmed Mohamed Ismaeel,3 Mohamed Ahmed Ibrahim,1 Nassreldeen K Adam4

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Introduction: The high prevalence of type 2 diabetes mellitus was associated with an increase in WC, BMI, and therefore obesity in the Sudanese population which may be due to low physical activity and absence of routine exercises. Because there is little data on the metabolic effects of adipocytokines leptin (Lep) in the diabetic Sudanese population this study aims to find the association of Lep and obesity with increased risk of type 2 diabetes mellitus. A case-control study was made at Abu A?gla health center for diabetic care at Wad Madani, Gezira State, Sudan, during the period of April 2012-March 2013. A total of one hundred eighty-one were enrolled in the study, participants divided into diabetic and nondiabetic groups to estimate the levels of Lep, fasting plasma glucose (FPG), and HbA1c. A questionnaire including personal information was filled as well as anthropometric and biochemical measures. Venous blood was collected after an overnight fast. Statistical analysis was carried out using a statistical package for social sciences (SPSS version 16, Chicago, IL, USA).

Method: Samples were analyzed for different biochemical parameters, using A15, a random access auto-analyzer biosystem. Lep was measured by ELIZA according to the method of the human leptin ELISA kit. This kit allows the determination of Lep concentration in human serum, plasma, and other biological fluids.

Result: Analysis of variance (ANOVA) revealed that mean FPG and HbA1c concentration in the diabetic group were increased significantly than that in the non-diabetic group; F=(8,250)=(p=<0.0001) and F=(2.933) (p=0.056). Correlation analysis revealed that FPG and HbA1C had strong positive significant correlation with Lep concentration (r=0.198**, p=0.007) at 0.05 and (r=0.153*, p=0.040) at 0.01 respectively. WC and BMI mean was (98.06) and (29.01) respectively.

Conclusion: The main finding in this study was that; the Sudanese participants with type 2 diabetes had a normal mean concentration of adipocytokines Lep (6.9813ug/L) compared to the standard values. FPG, HbA1c, and Lep in the diabetic group had a significant mean concentration (<0.0001), (<0.0001), and (0.056) respectively compared with the nondiabetic group. FPG and HbA1c had a strong positive significant correlation (p=0.007) and (p=0.040) respectively with Lep concentration. BMI and WC had no significant correlation with Lep concentration.


leptin, type 2 diabetes mellitus, BMI, WC, Sudan