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Leishmaniasis: still a diagnostic challenge?

Journal of Dermatology & Cosmetology
Villa RT, Rios RT, Tranquillini G, Zorzetto IFH, Silva TA

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American cutaneous leishmaniasis (ACL) should be differentiated from traumatic ulcers, venous ulcers, tropical ulcer, lower limb ulcers due to sickle cell anemia, pyodermatitis, paracoccidioidomycosis, syphilis, cutaneous neoplasms, among others.1 Histopathology may be suggestive, but it is rarely specific enough to make the diagnosis without identification of the amastigote forms of the parasite.2 Among the non-specific alterations to the histopathological examination, pseudoepitheliomatous hyperplasia (PEH) presents as a challenge, especially in the differential diagnosis with squamous cell carcinoma (SCC).


leishmaniasis, pseudoepitheliomatous hyperplasia, carcinoma, systemic treatments, erythematous plaque, insect bites