Mimosa caesalpiniifolia (Fabaceae), a medicinal plant from Brazilian cerrado with antioxidant and antiinflammatory properties
- International Journal of Complementary & Alternative Medicine
Marcelo José Dias Silva,1 Fernando Pereira Beserra,2 Vinícius Peixoto Rodrigues,3 Marcelo Aparecido da Silva,4 Geraldo Alves da Silva,4 Clélia Akiko Hiruma-Lima,3 Wagner Vilegas1
Ethnopharmacological relevance: Mimosa caesalpiniifolia(EEM) popularly known as “sabiá” or “sansão-do-campo” is a Brazilian Northeast native perennial tree used for several purposes and in traditional medicine is used for inflammatory diseases, hypertension and fungal infections.
Aim of the study:The objective of this study was to evaluate the anti-inflammatory and antioxidant activities of the hydroalcoholic extract of EEM leaves encapsulated with aerosil® 20%, as well as the identification of chemical compounds.
Material and methods:The antioxidant activity of EEM leaf hydroalcoholic extract was determined by using both the 1,1-diphenyl-2-picrylhydrazyl radical scavenging and the oxygen radical absorbance capacity in vitro assay. The phytochemical study of EEM was analyzed by experiments with FIA-ESI-IT-MSn (Direct Flow Analysis-ionization Electrospray Ion Trap Tandem Mass Spectrometry). Anti-inflammatory properties of EEM was evaluated in ear edema induced by xylene in rats.
Results:The phytochemical investigation of EEM resulted in the identification of flavonoids glycosides(m/z563,579,621) and derivativesof catechin(m/z595,611,741 and757). EEM leaf extract had antioxidant and anti-inflammatory properties. EEM (125 and 250mg/kg, p.o.) significantly inhibited the ear edema induced by xylene (52% and 64% respectively).
Conclusion:Our results show a good EEH performance in the anti-inflammatory effect in the mouse ear edema model. These results support the ethnopharmacological use of Mimosa caesalpiniifoliain folk medicine.
mimosa caesalpiniifolia, flavonoids, anti-inflammatory, antioxidant, hydroalcoholic extract, inflammatory diseases, hypertension, electrospray ionization, ion trap, arbitrary units, oxygen radical absorbance capacity