Clinical approaches of polysaccharides used for cancer cell inhibition as novel biomaterials
- Advances in Tissue Engineering & Regenerative Medicine: Open Access
Fadeeva IV,1 Fomin AS,1 Trofimchuk ES,2 Rogatkina EV,1 Davidova GA,3 Barinov SM,1 Ignatyeva GN4
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Biomaterials for regenerative medicine may include mineral-polymer matrices based on the starch, chitosan and CP with different Ca/P ratios. Crystals connecting with the polymer matrix are combined into 200-300 μm agglomerates, which are evenly distributed over the film surface. This paper successfully has demonstrated that the films of starch-chitosan mixture don’t have a toxic effect. Research results show that pectin hydrogels can be used as biomaterials for cell delivery in regenerative medicine, etc. Modified pectins and nanopectins can be obtained from agricultural raw materials or from industrial pectin. The method of pectin modification is analyzed by HPLC, SEC, etc. In most cases, modified pectin has a nano rodlike structure. According to our results samples of chitosan, pectin, and modified pectin are demonstrated a significant induction of cell differentiation during experiments. As shown, cells treated with adipogenic agents which also contained 1000 μg / ml of the modified pectin accumulated more 20 ± 2% of intracellular triglycerides compared to the control sample treated with the same agents.
polysaccharides, porous biodegradable matrices, tissue engineering, modified pectin, inhibition of cancer cell