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Spectrum of acute hepatitis b at tertiary care center of northern India


Gastroenterology & Hepatology: Open Access
Parveen Malhotra,1 Vani Malhotra,2 Usha Gupta,3 Gill PS,4 Pushkar,4 Yogesh Sanwariya5

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Abstract

Introduction: Hepatitis is often a viral infection and hepatitis B virus (HBV) is reason in significant proportion of cases worldwide. HBV impact on liver can be of varying severity ranging from acute hepatitis to chronic hepatitis which can further lead to chronic liver disease, liver cirrhosis and hepatocellular carcinoma (HCC). There is paucity of data on acute hepatitis B, thus more researches will lead to better understanding of epidemiology and planning appropriate strategies required for prevention and control. 
Aims and objectives: The aim was to study Clinico-epidemiological profile in patients having acute infection of HBV and to assess the various risk factors, age & sex distribution and geographic foci of the disease, if any. 
Materials & methods: It was an epidemiology based, prospective study conducted at Medical Gastroenterology Department,PGIMS,Rohtak over a period of three years . Four hundred and nine (409) patients who were found to be having features of acute hepatitis and confirmed to be positive for HbsAg on Enzyme linked Immunoassay test (ELISA) and HBV DNA on PCR testing were enrolled in the study.
Results: The burden of acute hepatitis B infection is more in the young males especially in the rural areas i.e. residing in villages. The reason for this could be lack of awareness, hygiene and shortage of health facilities.
Introduction: Hepatitis is often a viral infection and hepatitis B virus (HBV) is reason in significant proportion of cases worldwide. HBV impact on liver can be of varying severity ranging from acute hepatitis to chronic hepatitis which can further lead to chronic liver disease, liver cirrhosis and hepatocellular carcinoma (HCC). There is paucity of data on acute hepatitis B, thus more researches will lead to better understanding of epidemiology and planning appropriate strategies required for prevention and control. 
 
Aims and objectives: The aim was to study Clinico-epidemiological profile in patients having acute infection of HBV and to assess the various risk factors, age & sex distribution and geographic foci of the disease, if any. 
 
Materials & methods: It was an epidemiology based, prospective study conducted at Medical Gastroenterology Department,PGIMS,Rohtak over a period of three years . Four hundred and nine (409) patients who were found to be having features of acute hepatitis and confirmed to be positive for HbsAg on Enzyme linked Immunoassay test (ELISA) and HBV DNA on PCR testing were enrolled in the study.
 
Results: The burden of acute hepatitis B infection is more in the young males especially in the rural areas i.e. residing in villages. The reason for this could be lack of awareness, hygiene and shortage of health facilities.
 

Keywords

HbsAg, hepatitis B surface Antigen, ALT, alanine transferase, ELISA, enzyme linked immunoassay, PCR, chain reaction, CI, confidence intervals, hepatitis B, acute hepatitis B, HbsAg, tattooing, blood transfusion

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