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The role of oxidative stress and the underlying biological pathways in the pathogenesis of Parkinson’s Disease


International Journal of Complementary & Alternative Medicine
Chelsea Leonce,1 Amrut Patel,2 Bela Peethambaran1,2

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Abstract

In this review, we present evidence collected over a decade concerning signaling pathways and pathogenic mechanisms that are associated with oxidative stress in Parkinson’s disease. Parkinson’s is associated with several protein such as α-synuclein and signaling pathways such as Wnt signaling pathway. The review highlights the connection of the Wnt mediated pathway with other biological pathways that are known to have a role in neurodegeneration and the orchestrated role of several proteins in mitochondrial oxidative stress in Parkinsons. We have highlighted neuroprotective agents that eliminate the excess of reactive oxygen species and have a potential to be developed as therapeutics for Parkinson.

Keywords

PD, parkinson’s disease, iNOS, induced nitric oxide synthase, NO, nitric oxide, PUFAs, polyunsaturated fatty acids, Parkinson’s, Oxidative stress, natural treatments for Parkinson’s, biological pathways

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