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Evaluation the efficacy of three brands of ceftriaxone against various strains of bacteria by measuring zone of inhibition


Pharmacy & Pharmacology International Journal
Ibrahim Egfair,1 Ryad MO Alati,1 Abdullah MO Bakoosh,2 Abu Ajeela M Alfalos,2 Mahmoud AL Ruaua,3 Ashraf A Naass,3 Waleed RA Abusittah,4 Mahmud EL Abushhewa4

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Abstract

Ceftriaxone (Rocephin) is wide spectrum cephalosporin that has been used for decades for combating infections caused by broad array of pathogens. In this study, the antibiotic ceftriaxone from three different brands was tested for its effectiveness against strains of bacteria like Streptococcus pyrogenes, Staphylococcus aureus and Klebsiella pneumonia. The effectiveness of ceftriaxone was estimated by measuring zone of inhibition and compared with standard disc (BD BBL Sensi-Disc 2004/09). The diameters of the inhibitory zones for all brands were ranged from 20 to 33mm±0.5.The present study showed that there is no significant variation amongst the different brands of ceftriaxone in term of their antibacterial effectiveness.

Keywords

ceftriaxone, zone of inhibition, antibacterial efficacy

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