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The main differences between vulvar intraepithelial neoplasia and vulvar intraepithelial lesion

Obstetrics & Gynecology International Journal
Vivian de Oliveira Rodrigues Brum,1 Denise Gasparetti Drumond,2 Neila Maria de Góis Speck,3 Gabriel Duque Pannain,4 Giovana Moreira Bordim5

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Vulvar cancer is a recurrent subject in gynecological cancer. Vulvar Intraepithelial Neoplasia is known for being a precursor lesion of vulvar cancer and can be divided in three different subtypes: Low-grade Vulvar Intraepithelial Lesion (vulvar LSI), High-grade Vulvar Intraepithelial Lesion (vulvar HSIL) and Differentiated Vulvar Intraepithelial Neoplasia (dVIN). These subtypes differ in several aspects, and this article aims to present those differences in order to facilitate its treatment and the final diagnosis. The HSIL is the most associated with cronic Human Papilloma Virus (HPV) infection and can be related to other environment factors. As for dVIN, it’s more frequent in post-menopausal women with sclerosis lichen and it has a higher rate of progression to vulvar squamous carcinoma. The difference must be made in order to choose what is the best treatment, once there are various modalities, such as simple excision, CO2 ablation and topical application of imiquimod or fluoracil. This differences is also important for the development of measures that seek specific prevention, such as HPV vaccine for the HSIL and the proper treatment of vulvar conditions for the dVIN.


Vulvar cancer, Vulvar intraepithelial neoplasia, Human papilloma virus, Concomitant infection