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Successful management of severe lupus crescentic nephritis and pneumonitis with weekly cyclophosphamide and plasmapheresis


Urology & Nephrology Open Access Journal
Ahmed Akl,1,7 Nahid Janodi,2 Souha Issa,3 Nabih Hammad,4 Wail Tashkandi,4 Sayed Asghar,5 Hassan A Shabana,5,8 Nezar Bahabri,6 Hanadi Alhozali,1  Mohamed Azzam4

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Abstract

Systemic   lupus   erythematosus   (SLE)   may   present   with   a   variety   of   pulmonary   manifestations. The most common is infection however lupus pneumonitis can be presented with  a  picture  like  infectious  pneumonia.  Lupus  pneumonitis  is  a  high  suspicious  in  a  postpartum young female presenting with pulmonary infiltrates. Type II rapidly progressive glomerulonephritis (RPGN) caused by immune complexes deposition accounts for 25% of RPGN. In-here, we present a catastrophic lupus pneumonitis and RPGN who responded well to intensive protocol of weekly cyclophosphamide and plasmapheresis.

Keywords

lupus pneumonitis, lupus erythematosus, cyclophosphamide, plasmapheresis, pulmonary infiltrates, antibodies

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