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Immunomodulatory effects of proteolytic enzymes: meteoric brief review


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Abstract

Proteolytic enzymes play crucial roles in digestion and immunomodulatory functions. Proteolytic enzymes commonly found naturally in foods and other naturally occurring supplements like papaya, pineapple, kiwi, ginger etc. Proteolytic enzymes based therapies have proposed these days to treat many immune diseases due to having non-toxic and healthy version of naturopathy immunomodulatory alternatives due to having their unique pathophysiological mechanisms. These immunomodulatory effects are commonly carried out by trypsin enzyme due to the activation of specific T lymphocytes to carry out immunomodulatory effects. Trypsin is reported a normal constituent of the serum with normal concentration of 300mg/1 especially in intestinal origin. Their respective pathophysiological mechanisms of immunomodulation are found to have their role to improve inflammatory responses in renal diseases like interstitial nephritis and glomerulonephritis. These kinds of immunomodulatory effects are found to happen due to the activation and production of expansion of specific T lymphocytes. Serum proteases and serum trypsin are usually bound to the antiprotease, alpha 2 macroglobulin to form complex which is protected from autodigestion and degradation by other serum proteases to retain its own enzymatic activity to carry out immunomodulatory effects.

Keywords

proteolytic enzymes, serum trypsin, serum proteases, immunomodulatory effects, protein digestion, immune function

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