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A Personalized and precision medicine framework in the treatment of pre-existing conditions in coronavirus disease 


Journal of Human Virology & Retrovirology
Ewaoche Sunday Itodo, Yibala Ibor oboma, Tolulope Alade

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Abstract

In healthy individuals, the immune system processes pathogens with a natural immune response that is mild and non-lethal; however in those that are immune-compromisedelderly and those with pre-existing conditions- diabetes, high blood pressure, dysbiosis and chronic liver disease etc., their immune system may overreact; and in the case of COVID-19, attacking lung epithelial cells and tissues resulting in vitamin A deficiency which shrinks the epithelial cells. Continuous exposure to this chemical stressor by the virus will result in squamous keratinization of the skin, digestive tract, respiratory tract, genitourinary system etc. leading to symptoms of dry skin, diarrhoea, coughing, keratomalacia associated with coronavirus leading to hospitalization and mortality. The immune cells notably the macrophages, neutrophils, natural killer cells etc. become weakened and dysfunctional especially among the elderly with chronic diseases. Boosting the immune system holds sway for infectious diseases (COVID-19) and non-communicable diseases rather than the reductionist science of modern allopathic medicine.

Keywords

COVID-19, cytokine storm, vitamin A, hypertension, personalized medicine

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