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Does serological evidence of prior infection with SARS-CoV-2 indicate immunity


Journal of Bacteriology & Mycology: Open Access
Adan Bashir, Joshua F Potter, Eric Sin

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Abstract

1. Abstract
As the novel coronavirus 2019 (SARS-CoV-2) pandemic has developed worldwide, epidemiologists, infectious disease specialists, and public health officials, among other invested parties, have grappled with the question of to what degree viral re-infection and/or re-activation are issues of concern.1,2 SARS-CoV-2 infected patients tend to develop an antibody response, and there are hopes that this represents immunity on the behalf of serologically positive patients.3,4 Here we present two cases where a patients presented with symptomatic SARS-CoV-2 infection while simultaneously exhibiting positive antibody tests. One of the goals of SARS-CoV-2 antibody tests is to determine who is still at risk of infection.5 However it is still not clear if infection confers immunity.6,7 There has also been question as to the reliability and accuracy of these tests.8 These cases demonstrate that there are still many unknowns with regards to SARS-CoV-2 testing, particularly with regards to immunity and vaccine development.9–11. 
As the novel coronavirus 2019 (SARS-CoV-2) pandemic has developed worldwide, epidemiologists, infectious disease specialists, and public health officials, among other invested parties, have grappled with the question of to what degree viral re-infection and/or re-activation are issues of concern.1,2 SARS-CoV-2 infected patients tend to develop an antibody response, and there are hopes that this represents immunity on the behalf of serologically positive patients.3,4 Here we present two cases where a patients presented with symptomatic SARS-CoV-2 infection while simultaneously exhibiting positive antibody tests. One of the goals of SARS-CoV-2 antibody tests is to determine who is still at risk of infection.5 However it is still not clear if infection confers immunity.6,7 There has also been question as to the reliability and accuracy of these tests.8 These cases demonstrate that there are still many unknowns with regards to SARS-CoV-2 testing, particularly with regards to immunity and vaccine development.9–11 
 

Keywords

coronavirus, COVID19, severe acute respiratory syndrome coronavirus 2, pandemics, immunity, immunization

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