Features of disturbances of functions of cellular membranes in patients with chronic kidney disease, treated with programmed hemodialysis
- Urology & Nephrology Open Access Journal
Kazakova Irina Aleksandrovna, Yevgeniy Nikolaevich Ievlev
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In recent years, there has been a steady increase in the number of patients receiving programmed hemodialysis due to the annual increase in the capacity of the dialysis centers, the progression of socially significant diseases, such as diabetes mellitus, arterial hypertension, etc. In the last decade, there has been a significant improvement in the quality of the dialysis procedure, and as a result, the number of patients with a long-term dialysis experience is growing.1–3 Stage 5 chronic kidney disease (CKD) is accompanied by a disturbance of all the functions of the body’s systems and is reflected in a change of intracellular processes, including a disturbance of the structural and functional properties of cell membranes. The works from the list of references indicate that destabilization of red blood cell (RBC) membranes can be influenced by such systemic and organ factors as tissue ischemia, microbial or immune inflammation. The level of nonspecific membrane stabilizing processes reveals the nature of damage in organs and organsystems.4,8,17,19 In vivo study of the properties of cell membranes can directly and indirectly assess the regulation of all biological processes in the cells of the body.8,15 The surface electric charge of the membrane is one of the main physical characteristics of RBC, the value of which is estimated by their electrophoretic mobility.
Electrophoretic mobility of erythrocytes (EME) is the ability of RBC to move in an electric field with a speed depending on the value of their surface electric charge of the membrane.RBC must have a stable value of the surface electric charge for the adequate functioning and maintenance of homeostasis of the body. The physical and chemical state of the cell membrane (along with the composition of the environment surrounding the cell) has a crucial influence on the value of EME. In the literature there are publications indicating a decrease in the electric charge of RBC in sepsis, intestinal diseases, viral diseases, pneumonia, rheumatic diseases, as well as under stress.1–8,16,18,20 Terminal conditions, such as CKD 5D, cause changes in the density of the surface electric charge of the blood corpuscles, which are accompanied by a disturbance of the stability of the cell suspension and functional activity of cells. Thus, the electrophoretic mobility of RBC in hemodialysis patients is virtually unexplored. The emergence of new data is necessary, including, information about the impact of drug therapy on the charge of RBC membranes for the further appointment of adequate therapy.
electrophoretic mobility of erythrocytes, chronic kidney disease, hemodialysis, hypertension, antihypertensive therapy