Immune thrombocytopenia in patient with clear cell renal carcinoma: case report and literature review
- International Journal of Family & Community Medicine
Mart nez-Cordero Humberto, Salgado-Reyes Paula, Alcala-Lara Sebastian, Linares-Pati o, Maximo Mejia, Angie Ramos Robert
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Paraneoplastic secondary immune thrombocytopenia is a rare disorder; however, this entity may delay the timely treatment of the underlying cancer due to the limiting side effects of therapy. There are few reported cases of immune thrombocytopenia associated with clear cell renal carcinoma and it is described that they may have a good response to glucocorticoids and immunoglobulin.
Case report: We present here the case of a 70-year-old patient with a diagnosis of clear cell renal carcinoma with associated severe thrombocytopenia that was initially diagnosed as disseminated intravascular coagulation lasting several months without recovering the platelet count and therefore the patient could not initiate anticancer therapy timely. Subsequently, the diagnosis was redefined to secondary immune thrombocytopenia after a detailed analysis of the blood count and to achieve a good response with the use of oral prednisone. The objective of this report is to describe the association of some solid neoplasms with immune thrombocytopenia, the potential benefit of systemic glucocorticoid therapy, which may allow timely directed therapy for these patients.
clear cell metastatic renal cell carcinoma, autoimmune thrombocytopenia