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Pseudomonas balearica DSM 6083T promoters can potentially originate from random sequences

MOJ Proteomics & Bioinformatics
Sharlene Usman,1,2 Jing Wen Chua,1,2,# Keerthana D Ardhanari-Shanmugam,1,2,# Chakrit Thong-Ek,1,2,# Vicnesh B,1,2,# Khadija Shahrukh,1,2,# Jun Hong Woo,1,2,# Brenda ZN Kwek,1,2,# Maurice HT Ling1,2,3

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Recent studies and researches have proposed that many genes are plausibly emerged from previously non-coding genomic regions. However, how a promoter can emerge and function properly from de novo genes remain debatable as this has not been show in large numbers of organisms. Therefore, this study aims to explore the possibility of de novo evolution of a promoter from random sequences by using Pseudomonas balearica DSM 6083T as the model organism. Our result shows that 39.3% of the generated random sequences have 68.6% probability to be a functional promoter. Evolution simulation was carried out to observe the effect of evolution in the putative P. balearica promoter over generations. The simulation result proves that selection enhances the functionality of the generated random sequences overtime. Therefore, it is plausible that P. balearica promoter could emerge from random sequences, which is consistent with findings from previous studies.


Balearica, 6083T, subtilis, origination, prediction