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2, 4-Dinitrophenyl hydrazone derivatives as potent of alpha amylase inhibitors

Journal of Analytical & Pharmaceutical Research
Amir Hassan, Muhammad Yousaf, Shakeel Ahmad, M Idrees, M Adil, Huma Zia, Mirajul Haq, Shah Faisal, Kainat


In our current study thirteen new 2,4-dinitrophenyl hydrazone derivatives1–13 were evaluated for alpha amylase activity. The molecular docking results indicate that compounds potentially bind in the catalytic site of the enzyme with excellent result. Molecular Operating Environment (MOE) software was used for docking study. 2,4-dinitrophenyl hydrazone1–13 were obtained under reflux conditions by reacting dinitrophenyl hydrazine in methanol with different aromatic as well as aliphatic aldehydes using acetic acid act as a catalyst. Our results has shown that compounds 5 (IC50=12.16µg/mL), 6 (IC50=15.03µg/mL), and 12(IC50=16.42µg/mL), were found to be the more potential alpha amylase inhibitors as compared to the standard acarbose (IC50=42.47µg/mL). These compounds may lead better for alpha amylase inhibitor and further assessment of these compounds provide great help in the discovery of new anti diabetic drugs.


schiff’s bases, 2,4-dinitrophenyl hydrazone, alpha amylase activity, molecular docking