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Serum irisin levels in chronic open-angle glaucoma

Advances in Ophthalmology & Visual System
Burak Turgut,1 Kadir Mercan,2 Nevin Ilhan,3 Onur Çatak4


Purpose: To evaluate the levels of irisin in the serum in patients with chronic open-angle glaucoma.
Materials and methods: In this institutional comparative clinical study, the serum irisin levels of age and sex-matched 15 healthy volunteers as controls (Group 1), 15 patients with normal-tension glaucoma (NTG) (Group 2), 15 patients with pseudo-exfoliative glaucoma (PXG) (Group 3) and 15 patients with primary open-angle glaucoma (POAG) (Group 4) were measured with the enzyme-linked immune-sorbent assay (ELISA) method, and were evaluated.
Results: There was no statistically significant difference concerning age and gender among the groups (p>0. 05). The mean serum irisin levels in Group 1, Group 2, Group 3 and Group 4 were 24.70±8.53 ng/mL; 15.61±3.56 ng/mL; 17.83±6.06 ng/mL and 16.49±3.39 ng/mL, respectively. Although the mean irisin levels in all glaucoma groups seem numerically lower than the control group, there was no statistically significant difference between the serum irisin concentrations of the study groups (p>0.05).
Conclusion: These findings suggest that serum irisin levels are not different among various open-angle glaucoma types. However, theoretically, irisin may contribute to the pathogenesis of glaucoma and may play a neuroprotective hormone in glaucoma. Further studies with large patient population are required for whether irisin plays a role in the pathogenesis of glaucomatous optic neuropathy.


open-angle glaucoma, irisin, serum levels