Home Magazines Editors-in-Chief FAQs Contact Us

Salt craving syndrome lead to hypertensive urgencies and rapid progression to end stage renal disease in destombes-rosai-dorfman disease: a case report and review of literature

Urology & Nephrology Open Access Journal
Ahmed Akl,1,2,3 Ahmad Mandurah,1 Alaa Habashi,1 Abdulrahman Qasem1


Many Dietary products over the human history have been considered a modifiable risk factor for causing Acute Kidney Injury (AKI) or progression of Chronic Kidney Disease (CKD). Salt is a highly addictive taste. Our brains and bodies are designed to enjoy salt because it is necessary for survival. Over the course of human history, finding salt was difficult, so craving salt was a survival mechanism. The American Heart Association recommends that adults consume between 1.5-2.4 grams (gm) of salt per day. That is no more than one teaspoon of salt per day. Most people take in close to 3.4 gm each day. However, craving salt may be a symptom of a health condition, and not just a yearning for a mid-afternoon snack. Salt craving syndrome can lead to complex medical situations, including uncontrolled hypertension and progressive renal damage ending with end stage renal disease requiring lifelong renal replacement therapy. Destombes-Rosai-Dorfman disease or sinus histiocytosis is characterized by massive lymphadenopathy. It is a rare proliferation of cells similar to histiocytes found in some patients. It can be idiopathic or post infectious and can be resolved spontaneously with no guidelines for directed therapy. In here, we report a young female who developed a post-delivery depressive illness associated with salt craving of 2,250-3,000 gm of salt daily. She suffered uncontrolled hypertension, progressive salt and water retention, generalized lymphadenopathy, and inguinal lymph node biopsy revealed sinus histiocytosis. She suffered progressive renal damage that required haemodialysis therapy in two years. In conclusion, salt craving is not uncommon, especially in females, and is associated with unflavoured outcomes, and may lead to end stage kidney disease if not well diagnosed.


food craving, renal failure, CKD, hypertension