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Histo-morphological study of full term placenta and anti-oxidant vitamin levels of selected normotensive and pre-eclamptic women in Bangladesh

Journal of Nutritional Health & Food Engineering
Nahid Ahmed Khan,1 Khaleda Islam2

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Pre–Eclampsia is a disorder of 2nd half of pregnancy which is characterized by a combination of hypertension, proteinuria and edema, secondary to decreased placental perfusion. It is commonly associated with reduced weight, diameter and volume of placenta, along with other microscopic changes. This study evaluated the plasma levels of antioxidants and the histomorphological variations of placenta in selected pre-eclamptic and normotensive pregnant women. A total of 220 pregnant women were selected with inclusion and exclusion criteria from 3 different medical colleges – Dhaka Medical, Mitford and Holy Family Red Crescent Medical College. In this study 56% of Pre-eclamptic women were in the age group of 18-24 years. This study reveals that mean placental weight in pre-eclamptic women was (404.80 kg) compared to normal pregnant women (486.96 kg) (p<0.001). It was observed that the mean diameter of placenta (15.88 cm) , the number of cotyledons (16) and the number of infarcted areas (16.02) in case of pre-eclamptic women compared to normal pregnant women were (18.22 cm), (17) and (4.02) respectively. Serum Vit C is below normal in 78% of pre-eclamptic women compared to normal pregnant women, where it was low in only 20%.serumVit E is below normal (68%) of pre-eclamptic women compared to normal pregnant women which was (20%). This study therefore indicates an association between deficiency of anti oxidants in blood and development of pre-eclampsia with histological and morphological changes in the placenta.