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The combined effect of anticholinesterase compound DDVP and its antidote cholinesterase reactivator carboxim on implementation of cholinergic anti-inflammatory pathway


Experiments on random-bred albino mice showed that the acute intoxication of anticholinesterase compounds (DDVP, 0.75 LD50) is implemented the cholinergic antiinflammatory pathway (reduced mortality of mice from sepsis and the blood concentration of pro-inflammatory cytokines TNF-α, IL-1β, IL-6). Sepsis caused by the intraperitoneal administration of saline diurnal culture of E. coli O157:H7 (2.5×109 CFUs). The use of the cholinesterase reactivator carboxim (15mg/kg)-antidote of organophosphorus compounds - after acute intoxication of DDVP diminished affect the implementation of the cholinergic anti-inflammatory pathway.


anti-inflammatory pathway, sepsis, E. coli, anticholinesterase compounds, cholinesterase reactivator, carboxim