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Arthropathy in patients with hemophilia in the antananarivo hemophilia treatment center

Hematology & Transfusion International Journal
Dinafanomezana Harijaona Raymondine,1 Rahantamalala Marie Ida,2 Randriamampianina Tahianasoa,3 Vololontiana Hanta Marie Danielle,4 Rakoto Alson Aimée Olivat5


Hemophilia is a hereditary bleeding disorder related to X chromosome due to a coagulation factor deficiency. Sixty six patients with hemophilia (PwH) A and fifty four patients with hemophilia B are until now registered at the HTC in Madagascar. The objective of this study is to describe the epidemioclinical and therapeutic profile of arthritis in Malagasy hemophiliacs at the HTC. This is a monocentric, retrospective and descriptive study extending over a period of 6 months from September 1, 2017 to March 31, 2018 including 30 cases of arthropathy. The age group between 11 and 20 and patients with hemophilia A severe were the most affected. Hemarthrosis has been frequent in 3 to 5 times a year. Arthropathy reached the knees in 70% of cases and has been debilitating in almost all of cases. Care has been essentially based on clot factor substitution. Repetition of hemarthrosis episodes leads to arthropathy which can be avoided by early infusion of concentrate clot factor.


arthropathy, hemarhtrosis, hemophilia, antihemophilic factor, Madagascar