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Role of intravenous tranexamic acid on cesarean blood loss: a prospective randomized study

MOJ Women's Health
Manal A Farahat


Background: Postpartum hemorrhage (PPH) is a major cause of maternal mortality globally. Tranexamic acid (an anti-fibrinolytic agent) is a novel approach to prevent this dreadful complication.
Aim of the work: The aim was to study the efficacy and safety of intravenous tranexamic acid in reducing blood loss during and after the lower segment cesarean section.
Patients and methods: In this prospective randomized clinical study, 200 mothers scheduled for elective CS were randomly selected and divided into two groups (study and control) of 100 each. The study group received 1 g IV tranexamic acid immediately before LSCS. And the control group received 30 ml of 5% glucose, all mothers received 10 units of oxytocin in 500 ml of normal saline.
Results: The mean intraoperative and postpartum blood loss was significantly lower in the study group than the control group.
Conclusion: Preoperative IV tranexamic acid significantly reduced blood loss during elective CS without any significant adverse effects.


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